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Over the counter supplements don't seem to be regulated in any way and are not classified as medication. As a result of they are not classified as a drug there is no regulation on distribution or producing and the companies do not have the power to create specific health-connected claims. The producing companies also sometimes don't have stringently performed clinical studies which provide the same info that a prescribed supplement might. Ephedra is one such example of a weight loss supplement that has a high rate of success but additionally a high side result profile that has hypertension, cardiac issues and even death. Hoodia Goldoni is another supplement that has each positive and negative press. There has been some credible weight loss reported with Hoodia however there are a few makers that can guarantee the authenticity and quality of the product they're delivering. There have also been research studies which have documented significant liver side effects in people who have used a supplement for weight loss.